FibroScan检测与慢性肝病临床诊断的相关性研究

目的探讨FibroScan在慢性HBV感染者肝纤维化诊断中的作用。方法选择我院364例进行FibroScan检测的慢性HBV感染者，获取FibroScan检测值（FS值），分析其与肝功能、肾功能和凝血功能指标及超声诊断等级的相关性。结果临床诊断为慢性乙型肝炎170例，肝硬化194例。肝硬化组FS值显著高于慢性乙型肝炎组（P〈0．05）。将FS值与临床检验指标进行多重线性回归分析，Fs值与ALB、国际标准化比值、CHE、ALP、ALT之间具有相关性，其中ALB对Fs值影响最大。不同超声诊断等级分组的Fs值差异有统计学意义（P〈0．05），FS值与超声诊断等级分组之间相关性较好（ra=0．670）。超声诊断为脾大但无肝硬化患者的FS值高于超声诊断无脾大、无肝硬化的患者（P〈0．05）。结论FibroScan在诊断慢性HBV感染者纤维化严重程度方面有较好的应用价值。

Correlation between FibroScan measurementand the clinical diagnosis in chronic liver diseases

Objective To evaluate the role of FibroScan （FS） in the assessment of liver fibrosis in chronic HBV-infected patients. Methods A total of 364 chronic HBV-infected patients, on whom liver stiffness measurement was performed by using FibroScan, were included in this study. FibroScan values （FS values） were observed, and the correlation between FS values and the markers of liver function, renal function and blood coagulation, and ultrasonic diagnosis degrees were evaluated. Results Of 364 patients, 170 were diagnosed with chronic hepatitis B （CHB group）, and 194 with liver cirrhosis （LC group）. FS values of LC group were significantly higher than those of CHB group （P〈0.05）. Multiple linear regression showed good correlation between FS values and albumin （ALB）, international normalized ratio, cholinesterase, alkaline phosphatase and ALT, and ALB influenced FS values the most. The FS values of the patients with different ultrasonic diagnosis degrees were significantly different （P〈O.05）, and the coefficient correlation between FS values and the groups of different ultrasounie diagnosis degrees was 0.670. FS values of the patients diagnosed with splenomegaly but without cirrhosis by uhrasonographic examination were higher than those of the patients without splenomegaly and cirrhosis （P〈O.05）. Conclusion FibroScan is a valuable method for assessing the severity of liver fibrosis in the patients with chronic HBV.