Synthesis, antibacterial, and antifungal activities of biolabile (E)-1-(4-morpholinophenyl)-3-aryl-prop-2-en-1-ones

Abstract  A collection of biolabile (E)-1-(4-morpholinophenyl)-3-aryl-prop-2-en-1-ones 8–13 are synthesized, characterized by melting point, elemental analysis, mass spectroscopy (MS), Fourier-transform infrared (FT-IR), and ¹H and ¹³C nuclear magnetic resonance (NMR) spectroscopic data and evaluated for their in vitro antibacterial and antifungal activities. Compounds 8–13 exerted a wide range of antibacterial activities against all tested Gram-positive and Gram-negative bacterial strains. All the compounds 8–13 were more active against Pseudomonas. Of the synthesized compounds, compounds 9 and 11 exhibited a wide range of antibacterial activities against Staphylococcus aureus, β-Heamolytic streptococcus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas. Compounds 10, 12, and 13 exerted strong antifungal activities against all tested fungal strains, namely Aspergillus flavus, Mucor, Rhizopus, and Microsporum gypsuem. Graphical Abstract