Effects of methylprednisolone on the neural conduction of the motor evoked potentials in spinal cord injured rats |
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| Authors: | Lee Bae Hwan Lee Kyung Hee Yoon Do Heum Kim Un Jeng Hwang Yong Soon Park Sang Keun Choi Joong Uhn Park Yong Gou |
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| Affiliation: | Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. |
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| Abstract: | Methylprednisolone(MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury(SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to saline-treated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI. |
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| Keywords: | Spinal Cord Injuries Methylprednisolone Behavior Evoked Potentials Recovery of Function |
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