缺血性脑卒中患者脑微出血与脑白质病变的相关性研究

目的 探讨缺血性脑卒中患者脑微出血与脑白质病变的相关性。方法 选取2018年1月-2019年12月本院收治的缺血性脑卒中患者; 通过核磁共振成像扫描患者头部观察各脑区脑微出血、脑白质病变情况,并对脑微出血情况进行分级,对脑白质病情情况进行评分; 采用Logstic回归分析法分析各危险因素与脑微出血、脑白质病变的关系; 通过spearman相关分析法分析脑微出血分级与脑白质病变评分的相关性。结果 有脑微出血患者中皮质及皮质下出现脑微出血占比61.46%明显高于基底及丘脑23.96%及幕下区41.10%(P<0.05); 有脑白质病变患者中额区脑白质病变占比69.44%明显高于颞区14.81%、顶枕区6.48%、基底节3.70%(P<0.05); Logstic回归分析显示年龄>60岁、有高半胱氨酸血症及合并心房颤动是发生脑微出血的独立危险因素(P<0.05),年龄>60岁是发生脑白质病变的独立危险因素(P<0.05); 脑微出血各级与脑白质病变各评分均呈正相关(r=0.327,0.311,0.401,0.362,P<0.05)。结论 年龄>60岁是缺血性脑卒中患者发生脑微出血及脑白质病变的危险因素; 在缺血性脑卒中患者中脑微出血与脑白质病变呈正相关

The correlation between cerebral microbleeds and white matter lesions in patients with ischemic stroke

ObjectiveTo investigate the correlation between cerebral microbleeds and white matter lesions in patients with ischemic stroke.Methods Patients with ischemic stroke admitted to our hospital from March 2017 to April 2019 were enrolled, and all underwent MRI examination. Thereafter, the cerebral microbleeds were graded and the condition of the white matter was scored, and the correlation between the two was determined by spearman correlation coefficient analysis. Logistic regression analysis was used to analyze the relationship between various risk factors and brain microbleeds, white matter lesions.Results The proportion of microhemorrhage in cortical and subcortical areas was significantly higher than that in basal thalamic and subtentorial areas(61.46% vs 23.96%, 41.10%, P<0.05). The proportion of white matter lesions in frontal region was significantly higher than that in temporal region(14.81%), parietal occipital region(6.48%)and basal ganglia(3.70%)(P<0.05). Logistic regression analysis showed that age >60 years, hyperhomocysteinemia and with atrial fibrillation were independent risk factors for cerebral microbleeds(P<0.05). Age >60 years was an independent risk factor for white matter lesions(P<0.05). The grading of cerebral microbleeds was positively correlated with the scores of white matter lesions(r=0.327, 0.311, 0.401, 0.362, P<0.05).Conclusion Age > 60 was an independent risk factor for cerebral microbleeds and white matter lesion in patients with ischemic stroke, the grading of cerebral microbleeds was positively correlated with the scores of white matter lesions