| 苦参素的免疫药理作用途径研究进展 |
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| 引用本文： | 吴甜甜,刘雪珂,刘妙华,金晶,蒋青青,刘端勇,赵海梅.苦参素的免疫药理作用途径研究进展[J].中药药理与临床,2020(1):234-238. |
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| 作者姓名： | 吴甜甜 刘雪珂 刘妙华 金晶 蒋青青 刘端勇 赵海梅 |
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| 作者单位： | 1.江西中医药大学研究生院;2.江西中医药大学研究生院2017级研究生院;3.江西中医药大学科技学院;4.江西中医药大学中医学院 |
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| 基金项目： | 国家自然科学基金项目(NO.81760808、81460679);江西省卫生计生委中医药科研课题(20185511、20185510、2017A248);江西省自然科学基金项目(NO.20181BAB205082、20171BAB205088、20171BAB215057);江西省教育厅科技项目(GJJ170733、GJJ171536)。 |
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| 摘 要： | 苦参素是从苦参等豆科植物的根中提取,其绝大部分成分为氧化苦参碱(Oxymatrine)的一类喹嗪类生物碱,已被证明具有抗炎、抗纤维化、抗肿瘤作用以及防止心肌损伤的作用等。苦参素通过体液免疫、细胞免疫及其与免疫相关的信号通路,如TLR信号通路、JAKs/STATs信号通路、PI3K/AKT信号通路等对免疫性或炎症性疾病有改善作用。这些研究显示出苦参素良好的药理作用,为治疗其他相关性疾病提供参考。
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| 关 键 词： | 苦参素 药理作用 免疫 信号通路 综述 |
Progress Research of the Immunopharmacological Pathway of Oxymatrine |
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| Wu Tiantian,Liu Xueke,Liu Miaohua,Jin Jing,Jiang Qingqing,Liu Duanyong,Zhao Haimei.Progress Research of the Immunopharmacological Pathway of Oxymatrine[J].Pharmacology and Clinics of Chinese Materia Medica,2020(1):234-238. |
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| Authors: | Wu Tiantian Liu Xueke Liu Miaohua Jin Jing Jiang Qingqing Liu Duanyong Zhao Haimei |
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| Institution: | (Graduate Student of Jiangxi University of Traditional Chinese Medicine,Jiangxi 330004;Science and Technology College,Nanchang,Jiangxi 330004;College of Traditional Chinese Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang,Jiangxi 330004) |
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| Abstract: | Oxymatrine is extracted from the roots of legumes such as Sophora flavescens,and most of its constituents are a class of quinolizine alkaloids of Oxymatrine( 氧化苦参碱),which have been proven to have anti-inflammatory,anti-fibrosis,anti-tumor effects and ability to prevent myocardial damage. Oxymatrine can improve immune or inflammatory diseases through humoral immunity,cellular immunity and immune-related signaling pathways such as TLR signaling pathway,JAKs/STATs signaling pathway,and PI3 K/AKT signaling pathway. These studies suggested good pharmacological effects of Oxymatrine and provided a reference for the treatment of other related diseases. |
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| Keywords: | Oxymatrine Pharmacological action immunity signaling pathway review |
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