| 激素难治性前列腺癌细胞对化疗药物敏感性的比较 |
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| 引用本文： | 张勇,胡笑克,陈维真,莫丛健. 激素难治性前列腺癌细胞对化疗药物敏感性的比较[J]. 标记免疫分析与临床, 2003, 10(2): 104-106 |
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| 作者姓名： | 张勇 胡笑克 陈维真 莫丛健 |
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| 作者单位： | 中山大学附属第三医院核医学科,广东,广州510630;中山大学实验核医学教研室,广东,广州510089 |
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| 基金项目： | 中山医科大学校科研和教改项目;9740; |
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| 摘 要： | 为临床选择激素难治性前列腺癌 (HRPC)的化疗方案提供参考 ,采用3 H -胸苷酸 (3 H -TdR)掺入法检测了 2 0例HRPC细胞对常用化疗药物的敏感性。HRPC对单药的敏感性依次为足叶乙甙 >阿霉素、5 -氟尿嘧啶、雌二醇氮芥 >长春花碱 >顺铂 ;两药联合可使敏感性进一步提高 ,依次为雌二醇氮芥 +足叶乙甙、5 -氟尿嘧啶 +阿霉素 >雌二醇氮芥 +长春花碱 >5 -氟尿嘧啶 +顺铂 ;三药联用抑瘤作用更强 ,雌二醇氮芥 +长春花碱 +阿霉素、5 -氟尿嘧啶 +阿霉素 +顺铂 >雌二醇氮芥 +长春花碱 +顺铂。对HRPC以联合化疗效果较好 , 3 H -TdR掺入法体外检测化疗药物的敏感性有助于化疗方案的选择
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| 关 键 词： | 前列腺肿瘤 癌 药物筛选试验 化疗 |
| 文章编号： | 1006-1703(2003)02-0104-03 |
| 修稿时间： | 2002-07-26 |
Comparative Study on Chemosensitivity for Hormone Refractory Prostate Cancer Cell |
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| ZHANG Yong ,HU Xiao-ke ,CHEN Wei-zhen ,et al.. Comparative Study on Chemosensitivity for Hormone Refractory Prostate Cancer Cell[J]. Labeled Immunoassays and Clinical Medicine, 2003, 10(2): 104-106 |
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| Authors: | ZHANG Yong HU Xiao-ke CHEN Wei-zhen et al. |
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| Affiliation: | ZHANG Yong 1,HU Xiao-ke 2,CHEN Wei-zhen 1,et al. |
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| Abstract: | To give reference to clinical chemotherapy scheme of hormone refractory prostate cancer (HRPC), 3H-TdR method was used to study the chemosensitivity to six chemical drugs in 20 cases of HRPC.The seguence of chemosensitivity to single drug was VP16>ADM,5-FU,EMP>VLB>DPP.Two drugs combination can elevate chemosensitivity,the seguence of which was EMP+VP16,5-FU+ADM>EMP+VLB>5-FU+DPP.Three drugs combination can improve chemosensitivity further,the segunce of which was EMP+VLB+ADM,5-FU+ADM+DPP>EMP+VLB+DPP.The combination chemotherapy might be suitable for HRPC. The 3H-TdR method might be helpful for the choice of clinical treatment plans. |
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| Keywords: | Prostatic neoplasms Carcinoma Drug screening assay Chemotherapy |
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