NRAMP1 polymorphism and susceptibility to lung tuberculosis in Surabaya, Indonesia |
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| Authors: | Nugraha Jusak Anggraini Rahayu |
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| Institution: | Department of Clinical Pathology, School of Medicine, Airlangga University, Surabaya, Indonesia. jusak.nugraha@yahoo.com |
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| Abstract: | The aim of this study was to evaluate the role of three polymorphisms (D543N, TGTG deletion in 3' UTR, INT4 G/C) of NRAMP1 to susceptibility to lung tuberculosis (TB) disease. The results showed that homozygous TGTG deletion in 3'UTR of NRAMP1 was found more frequent in lung tuberculosis patients than in healthy nurses working in a TB ward. This 4 base deletion might cause malfunction of NRAMP1 protein so that it fails as Fe2+ ion transporter causing macrophage unable to eliminate Mycobacterium tuberculosis. |
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