TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients

Authors:	Hsuan-Chi Wang Tzung Lieh Yeh Hui Hua Chang Po Wu Gean Mei Hung Chi Yen Kuang Yang Ru-Band Lu Po See Chen

Affiliation:	(1) Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan;(2) Institute of Biopharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan;(3) Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan;(4) Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan;(5) National Cheng Kung University Hospital, Dou-liou Branch, Yunlin, Taiwan;(6) Tainan Municipal Hospital, Tainan, Taiwan;(7) Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70428, Taiwan;

Abstract:	Rationale Tryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (MDD); however, its actual role is uncertain.

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