Pro12Ala polymorphism in PPAR gamma 2 associated with essential hypertension in Chinese nonagenarians/centenarians |
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Authors: | Lu Zhenchan Dong Birong Mo Xianming Chen Tie Wu Hongmei Zhang Yanling Xiao Hengyi |
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Institution: | aDepartment of Geriatrics, West China Hospital, West China Medical School, Sichuan University, No. 37 Guoxue Xiang, Ren Min Nan Lu, Chengdu, Sichuan Province 610041, China;bLaboratory for Stem Cell Biology, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province, China;cLaboratory for Geriatrics, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province, China |
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Abstract: | The Pro12Ala polymorphism of PPAR γ 2 has been shown to influence hypertension and the benefit of longevity in previous studies. We examined whether the polymorphism was related to essential hypertension among long-lived subjects ( 90 years). The Pro12Ala variant was examined using polymerase chain reaction restriction fragment length polymorphism in a population-based sample of 839 long-lived subjects (mean 94 years SD 4 years, aged 90–108 years). The genotype frequencies of the Pro12Ala polymorphism were 0.2% Ala12Ala, 9.4% Pro12Ala and 90.4% Pro12Pro in all participants. The frequency of the Ala12 allele was 3.45% in the hypertension group and 6.92% among the normotension group (P = 0.001). Moreover, in the total study population, Ala12 allele carriers had lower levels of triglycerides (1.03 ± 0.5 mmol/L (means ± SD) vs. 1.25 ± 0.61 mmol/L; P < 0.001). In conclusion, these results suggest that the Pro12Ala polymorphism of the PPAR γ 2 gene is associated with hypertension and triglycerides levels in Chinese nonagenarians/centenarians. |
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Keywords: | Polymorphism PPAR γ 2 Hypertension Elder Triglycerides |
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