| 慢性乙型肝炎与HLA-DRB1等位基因相关性的研究 |
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| 引用本文： | 褚瑞海,马立宪,王刚,邵丽华. 慢性乙型肝炎与HLA-DRB1等位基因相关性的研究[J]. 山东大学学报(医学版), 2005, 43(3): 267-269 |
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| 作者姓名： | 褚瑞海 马立宪 王刚 邵丽华 |
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| 作者单位： | 山东大学齐鲁医院感染病科,山东,济南,250012;山东大学公共卫生学院卫生教学实验中心,山东,济南,250012 |
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| 摘 要： | 目的:探讨人类白细胞抗原DRB1(HLA-DRB1)等位基因多态性与慢性乙型肝炎发生的相关性。方法:采用序列特异性引物聚合酶链反应技术(PCR-SSP),检测126例慢性乙型肝炎患者和76例健康对照的HLA-DRB1*03、*07、*09、*12、*15等位基因,并进行分析。结果:HLA-DRB1*07在慢性乙型肝炎组的等位基因频率明显高于对照组(P<0.05)。结论:HLA-DRB1*07与慢性乙型肝炎的发生呈正相关,可能是慢性乙型肝炎的易感基因。
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| 关 键 词： | 肝炎 乙型 HLA-DRB1抗原 等位基因 相关性 |
| 文章编号： | 1671-7554(2005)03-0267-03 |
| 修稿时间： | 2004-05-24 |
Correlation between chronic hepatitis B and HLA-DRB1 alleles |
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| CHU Rui-hai,MA Li-xian,WANG Gang,SHAO Li-hua. Correlation between chronic hepatitis B and HLA-DRB1 alleles[J]. Journal of Shandong University:Health Sciences, 2005, 43(3): 267-269 |
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| Authors: | CHU Rui-hai MA Li-xian WANG Gang SHAO Li-hua |
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| Abstract: | Objective: To investigate the correlation between chronic hepatitis B and the HLA-DRB1 alleles. Methods: HLA-DRB1*03, *07, *09, *12, *15 alleles in 126 patients with chronic hepatitis B and 76 normal control subjects were determined by PCR amplification with sequence-specific primers(PCR-SSP). Results: The frequences of HLA-DRB1*07 in the chronic hepatitis B group were significantly higher than those in the normal control group (P<0.05). Conclusion: HLA-DRB1*07 al-lele is closely associated with the susceptibility to chronic hepatitis B, and may be the susceptible gene. |
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| Keywords: | Hepatitis B HLA-DRB1 antigens Alleles Correlation |
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