| 姜黄素衍生物FM0807体内抗炎作用研究 |
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| 引用本文： | 叶丽香,王蜀平,余丽莉,许建华.姜黄素衍生物FM0807体内抗炎作用研究[J].海峡药学,2010,22(5):55-57. |
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| 作者姓名： | 叶丽香 王蜀平 余丽莉 许建华 |
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| 作者单位： | 福建医科大学药学院临床药理研究所,福州,350004 |
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| 基金项目： | 本课题受福建省科技厅重点项目资助(2009Y0025)许建华;E-mail:xjh@mail.fjmu.edu.cn 通讯作者 |
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| 摘 要： | 目的研究姜黄素衍生物FM0807的体内抗炎作用;方法通过建立二甲苯致小鼠耳廓肿胀、角叉菜胶致小鼠足跖肿胀、棉球植人法诱发慢性肉芽肿等炎症模型,探讨姜黄素衍生物FM0807的体内抗炎作用;结果姜黄素衍生物FM0807高、中、低各剂量对二甲苯致小鼠耳廓肿胀、角叉菜胶致小鼠足跖肿胀、棉球植人法诱发慢性肉芽肿均有明显的抑制作用;结论姜黄素衍生物FM0807对急、慢性炎症有明显的效果。
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| 关 键 词： | 姜黄素 衍生物 抗炎作用 |
Anti-inflammation effect of curcumin derivative FM0807 in vivo |
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| YE Li-xiang,WANG Shu-ping,YU Li-li,XU Jian-hua.Anti-inflammation effect of curcumin derivative FM0807 in vivo[J].Strait Pharmaceutical Journal,2010,22(5):55-57. |
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| Authors: | YE Li-xiang WANG Shu-ping YU Li-li XU Jian-hua |
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| Institution: | (Isstitute of clinical pharmacology,Fujian Medical University,Fuzhou,350004,China) |
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| Abstract: | OBJECTIVE To evaluate the Anti-inflammation Effect of Curcumin Derivative FM0807 in vivo.METHODS The models of ear edema induced by Xylene,paw edema induced by Carrageenin and chronic granulomatous inflammation induced by implanted Sponge Bob France in mouse were established.To evaluate the Anti-inflammation Effect of FM0807 in vivo.RESULTS High,medium and low doses of FM0807 were significantly inhibited ear edema induced by Xylene,paw edema induced by Carrageenin and chronic granulomatous inflammation induced by implanted SpongeBob France in mouse.CONCLUSION FM0807 was able to inhibit the acute and chronic inflammation. |
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| Keywords: | Curcumin Derivative Antineoplastic agents Anti-inflammation effect |
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