Three-dimensional axisymmetric flow-focusing device using stereolithography |
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Authors: | Yuya Morimoto Wei-Heong Tan Shoji Takeuchi |
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Institution: | (1) Center for International Research on MicroMechatronics (CIRMM), Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku Tokyo, 153-8505, Japan;(2) PRESTO, Japan Science and Technology Agency, Chiyoda-ku Tokyo, 102-0075, Japan |
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Abstract: | This paper describes a three-dimensional microfluidic axisymmetric flow-focusing device (AFFD) fabricated using stereolithography.
Using this method, we can fabricate AFFDs rapidly and automatically without cumbersome alignment needed in conventional methods.
The AFFDs are able to be fabricated reproducibly with a micro-sized orifice of diameter around 250 μm. Using this device,
we are able to produce monodisperse water-in-oil (W/O) droplets with a coefficient of variation (CV) of less than 4.5%, W/O
droplets with encapsulated microbes (CV < 4.9%) and oil-in-water (O/W) droplets (CV < 3.2%) without any surface modifications.
The diameter of these droplets range from 54 to 244 μm with respect to the flow rate ratio of the fluids used; these results
are in good agreement with theoretical behavior. For applications of the AFFD, we demonstrate that these devices can be used
to produce double emulsions and monodisperse hydrogel beads.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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Keywords: | Stereolithography Monodisperse 3D microfluidic channel Encapsulation Hydrogel |
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