老年糖尿病合并心绞痛者对麝香保心丸和缓释单硝酸异山梨酯的偏好比较

目的:了解老年糖尿病合并心绞痛者是偏爱麝香保心丸(SXBXP)(麝香、人参、牛黄等)还是缓释单硝酸异山梨酯(ERIM).方法:56例老年糖尿病合并心绞痛者,先经2周导入期后,随机接受SXBXP2粒、每日3次,或ERIM 60mg、每日1次,治疗4周;两组患者停药洗脱2周,随后,交叉接受另一药物治疗4周.治疗期间以日记卡形式记录心绞痛的发作次数和抢救药物的应用情况.研究结束时,所有患者完成由方便性、副作用和总的喜好倾向所组成的问卷.结果:两组心绞痛的发作次数和抢救药物的应用没有差异;71.4%的患者认为两药的使用同样方便;SXBXP副作用比ERIM少;总的来说,76.5%的患者偏好服用SXBXP.结论:相对ERIM而言,老年糖尿病合并心绞痛者更偏好于SXBXP.

Patient preference for Shexiang Baoxin Pill versus extended release Isosorbide 5-Mononitrate in elderly diabetic patients with angina pectoris

AIM: To gain an insight into preference for elderly diabetic patients with angina pectoris between Shexiang Baoxin Pill (SXBXP) (Moschus, Radix Ginseng, Calculus Bovis, etc.) and Extended Release Isosorbide 5-Mononitrate (ERIM). METHODS: Followed a two-week run-in, 56 elderly patients were randomized to take SXBXP 2 pills tid or ERIM 60 mg qd for 4 weeks; then followed a two-week wash-out, patients crossed over to the complementary therapy for another 4 weeks. Daily diary cards were used to record the side effects, the frequency of angina pectoris attacks and use of rescue medication. At the end of the study, participants were asked to complete a 3-item scale questionary to assess their angina pectoris treatment in terms of convenience, side effects and overall preference. RESULTS: No treatment difference in the frequency of angina pectoris attacks and use of rescue medication was found; 71.4% of patients thought use of SXBXP was the same convenient as that of ERIM; patients felt SXBXP had side effects fewer than ERIM and overall 75% of patients preferred SXBXP. CONCLUSION: Elderly diabetic patients with angina pectoris prefer SXBXP to ERIM.