Synthesis of sesquiterpene derivatives as potential antitumor agents; Elemane derivatives |
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Authors: | Bo Gil Choi Eun Yee Kwak Byung Ho Chung Won Jea Cho Seung Hoon Cheon |
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Affiliation: | College of Pharmacy, Chonnam National University, Kwangju, Korea. bgchoi@chonnam.ac.kr |
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Abstract: | Derivatives of elema-1,3-diene were synthesized in several steps as polar analogs of beta-elemene, antitumor agent under clinical phase. The lactone ring of compound 1 was opened by LiAlH4 to give diol 2 which was selectively protected by TBDPSCl. After acetylation of the secondary alcohol, the acetylated product was ozonolyzed and reduced to give elemane derivative 4 which was converted to diolefin 8 via selenides subsequent deprotection by tetrabutylammonium fluoride gave two compounds 9, 10. |
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Keywords: | β -Elemene Elema-1,3-diene Antitumor agent α -Santonin |
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