肝纤维化的SPIO增强磁共振成像研究

目的旨在通过动物肝纤维化模型的超顺磁性氧化铁（SPIO）增强磁共振（MR）研究,分析不同程度肝纤维化对SPIO增强效应的影响。方法肝纤维化大鼠21只及正常大鼠8只于注射SPIO前及60min后行T2加权MR扫描。测量图像的信号强度（SI）,计算信噪比（SNR）和信号强度变化百分比。肝脏标本行组织学检查,根据Scheuer的肝纤维化分期标准将大鼠分为4组。结果正常及肝纤维化组的SI及SNR于增强前后差异有显著性（P〈0.01）。肝纤维化分期与信号强度变化百分比的Spearman相关分析显示无相关性存在（P=0.212,r=0.239）。结论SPIO在肝纤维化与正常肝脏具有同样有效的增强作用。SPIO对肝脏增强效果的降低与慢性肝脏疾病的损害程度无显著相关。

Study on liver fibrosis by SPIO enhanced MRI

Objective] To evaluate the relationship of signal intensity （SI） changes in liver parenchyma with different degree of liver fibrosis on SPIO enhanced MRI. Methods] there are 21 rats with liver fibrosis and 8 normal rats. MR examination at 2.0 T using T2WI FSE sequence was performed for each rat before and 1 hour after SPIO injection. We measured SI ,SNR and SNR% before and after enhancement. Through histology exanfination of Liver example and according to Seheuer＇s criterion （0-4 grade）, all the rats were divided into 4 groups. Results] All groups had significant SI and SNR decrease after SPIO administration （P 〈0.01）. There was no direct relationship found between SI change and histological degree with Spearman correlation analysis. Conclusion] SPIO has the same enhancement in both normal liver and liver fibrosis. Nevertheless, the reduced enhancement is not directly related to the histological degree of liver fibrosis and cirrhosi, in this experimental study.