直接肾素阻滞剂Aliskiren预防早产儿视网膜病变

肾素作为肾素-血管紧张素系统（ｒｅｎｉｎ-ａｎｇｉｏｔｅｎｓｉｎｓｙｓｔｅｍ，ＲＡＳ）中上游生长因子，对ＲＡＳ链起着特异性限速的作用。在早产儿视网膜病变等缺血性视网膜病变中，ＲＡＳ上调，视网膜ＲＡＳ被激活，刺激血管内皮生长因子等上调，导致血管渗漏、血管内皮细胞增生和新生血管形成等血管病理性改变。直接肾素抑制剂Ａｌｉｓｋｉｒｅｎ作为阻断ＲＡＳ的新途径，在防止和减弱病理性血管生成的过程中发挥了明显作用。Ａｌｉｓｋｉｒｅｎ的应用有望成为早产儿视网膜病变的预防及治疗途径。

Direct renin inhibitors Aliskiren preventing retinopathy of prematurity

Renin, a upstream growth factor of renin angiotensin system( RAS) , has the effects of specific-speed-limiting on the RAS chain. In many ischenuc retinopathy cases such as retinopathy of prematurity ( ROP) , as the RAS increases , the RAS of retina is activated , which might stimulate the rise of vascular endothelial growth factor (VEGF) , result in vascular pathological changes, led to the leakage of blood vessels and the proliferation of vascular endothelial cell and neovascularization. Being adopted as a new way of blocking the RAS. Aliskiren plays a distinctive role in the process of preventing and abating pathological angiogenesis. The application of Aliskiren is becoming a promising approach for the prevention and treatment of ROP.