改良电痉挛治疗在老年难治性抑郁症维持治疗中的应用

目的 探讨改良电痉挛治疗（MECT）对老年难治性抑郁症急性期治疗和维持治疗的临床疗效和安全性.方法 对40例老年难治性抑郁症患者联合急性期MECT及维持期MECT,分别在MECT治疗前、急性期治疗结束、维持治疗3个月末、维持治疗6个月末,测评HAMD、 HAMA量表以评定疗效.用TESS、WMS量表、心电图评定不良反应.结果 （1）急性期MECT结束时与治疗前比较, HAMD、 HAMA评分均有明显下降;（2）所有入组患者在维持期MECT 3个月末、6个月末与治疗前比较,HAMD、HAMA评分均有明显下降;（3）急性期MECT有轻度不良反应.结论 联合MECT治疗对老年难治性抑郁症患者,不仅在急性治疗期有效,而且在维持期也可能提供了一个较好方法.

Utilization of MECT in maintenance therapy in elderly depression patients

Objective To explore the effect and tolerance of combining acute and maintenance MECT on the elderly depression patients. Methods 40 elderly depression patients were treated with combining acute and maintenance MECT. The HAMD and HAMA were used to rate the patients before the MECT, at the end of acute MECT, at the end of third and sixth month in maintenance MECT. The tolerance was evaluated by WMS and TESS. Results （1） Comparing the end with the before of acute MECT, the total scores of HAMD and HAMA were reduced significantly. （2）Comparing the end of third and sixth month in maintenance MECT with the before of acute MECT, the total scores of HAMD and HAMA were reduced significantly. （3）Acute MECT has mild side effect. Conclusions Combining MECT may be effective for the elderly depression patients not only in acute but also in maintenance therapy.