不同剂量甘露醇治疗急性大面积脑梗死病人其血清神经元特异性烯醇酶的变化

目的 探讨应用不同剂量甘露醇治疗急性大面积脑梗死病人时对其血清神经元特异性烯醇酶(NSE)的影响。方法 将急性大面积脑梗死病人分成两组,分别给予小剂量和常规剂量甘露醇治疗,均于发病后1、3、7、14d测定其血清NSE的浓度,比较两组病人同天内的测量值有无差别,并与正常健康人相对照。结果 两组病人起病后第1、3、7d血清NSE浓度较对照组显著升高(P<0.05),第3d最高,第14d NSE浓度与对照组比较无统计学意义(P>O.05)。两组间第1、3、7、14d NSE浓度分别比较均无显著性差异(P>0.05)。结论 急性大面积脑梗死病人应用小剂量甘露醇与应用常规剂量甘露醇治疗时,对于血清中NSE的变化具有一致的影响结果。

Diversification of neuron - specific enolase in blood of patients with acute big area cerebral infarction with management of different dosage of mannitol

Objective To investigate the effect on neuron - specific enolase(NSE) in blood of patients with acute big area cerebral infarction with management of different dosage of mannitol. Methods Patients with acute big area cerebral infarction were divided into two groups, each was respectively treatde with small dosage of mannitol or routine dosage of mannitol. Every patient was tested the concentration of serum NSE on the days of No. 1,3,7 and 14 after onset. The results of each day of two groups were compared, at the same time compared with the healthy pelple' s. Results The serum NSE values at 1,3 and 7 days after the stroke were higher than that of control group (P < 0.05) and peaked at 3 days, on more higher at 14 days (P > 0.05). The similar varities were appeared in the two case - groups, no signigicant difference was found between them ( P > 0.05). Conclusion The effect on serum NSE was same about the patients with acute big area cerebral infarction, no matter which were treated by small dosage of mannitol or routine dosage of mannitol.