针灸联合西药治疗阿尔茨海默病的Meta分析

目的：通过对随机对照试验的数据进行Meta分析，比较针灸联合西药和纯西药治疗阿尔茨海默病的疗效。方法：全面检索中文和外文有关数据库，收集比较针灸联合西药和纯西药治疗阿尔茨海默病的随机对照试验，提取数据后应用RevMan 5.2软件进行Meta分析。结果：共纳入10项符合标准的研究，将其中的7项报告了有效例数的研究进行Meta分析，合并RR=1.25[1.14，1.38]，漏斗图基本对称，提示针灸联合西药对阿尔茨海默病的治疗效果优于对照组（Z=4.66，P<0.01）；将其中的4项报告了治疗后简易智能精神状态量表（MMSE）评分的研究进行Meta分析，合并MD=2.87[0.64，5.10]，漏斗图基本对称，提示针灸联合西药对阿尔茨海默病在改善认知功能上优于对照组（Z=2.52，P=0.01）。结论：从目前的研究结果来看，针灸联合西药治疗阿尔茨海默病确实有效，但仍需进一步研究证实。

Meta-analysis on Acupuncture Combined with Western Medicine for Treatment of Alzheimer's Disease

This study was aimed to evaluate efficacy of acupuncture combined with western medicine in treatment of Alzheimer's disease (AD) with meta-analysis of data came from randomized controlled trials (RCTs). Databases both at home and abroad were comprehensively searched to collect efficacy data of acupuncture combined with western medicine versus western medicine in RCTs. The data was extracted from each study to conduct a meta-analysis with RevMan 5.2. The results showed that 10 studies measured up to standard. Seven studies reported effective cases were carried out by meta-analysis. The total RR was 1.25 [1.14, 1.38]. The funnel plot was approximately symmetry. It was suggested that effect of the therapy group was better than the control group (Z = 4.66, P<0.01). Four studies reported mini-mental state examination (MMSE) scores were carried out by meta-analysis. The total MD was 2.87 [0.64, 5.10]. The funnel plot was approximately symmetry. It was suggested that the therapy group was better than the control group on AD treatment in cognitive function improvement (Z = 2.52, P= 0.01). It was concluded that from current study, acupuncture combined with western medicine in AD treatment was definitely effective. However, it still required further study.