长效抗胆碱药物噻托溴铵的研究进展

噻托溴铵是长效抗胆碱能药物,主要作用于M3受体,具有长效而持续的支气管扩张作用,在慢性阻塞性肺疾病患者管理中的应用获得肯定.还能抑制黏蛋白分泌、抑制气道重塑、具有抗炎作用.因此,对哮喘和其他黏液高分泌性疾病具有一定的治疗作用.

Progress of long-acting anticholinergic named as tiotropium

Tiotropium is the long-term anticholinergic drugs, which majored in the M3 receptor and presents a long-term and sustained bronchodilation. This confirmed mechanism is used in the management of COPD patients. Except for this usage, tiotropium can inhibit mucin secretion, inhibition of airway remodeling,have anti-inflammatory effect. Therefore, tiotropium may be added to the management of asthma and other diseases of mucus hypersecretion.