首页 | 本学科首页   官方微博 | 高级检索  
检索        

CA125与HE4联合检测在子宫内膜癌诊断中的价值
引用本文:赖小青,张帆.CA125与HE4联合检测在子宫内膜癌诊断中的价值[J].北方药学,2016(4):194-195.
作者姓名:赖小青  张帆
作者单位:深圳南山医院妇科 深圳 518052
摘    要:目的:探讨CA125与HE4联合检测在子宫内膜癌诊断中的价值。方法:分别检测20例正常子宫内膜者、41例子宫内膜不典型增生患者、38例子宫内膜癌患者的血清CA125与HE4水平,并对结果进行统计学分析。结果:子宫内膜癌患者中血清HE4及CA125水平均明显高于子宫内膜不典型增生组和对照组,差异有统计学意义(P<0.05);晚期子宫内膜癌患者血清CA125、HE4水平均明显高于早期患者,差异有统计学意义(P<0.05);HE4与CA125诊断子宫内膜癌敏感性相当(39.47%VS 34.21%),差异无统计学意义(P>0.05),但联合检测敏感性为57.89%,较单项检测均有提高,差异有统计学意义(P<0.05),但是血清HE4比联合检测具有更高的特异性(P<0.05),其阳性预测值显著高于CA125(P<0.05)。结论:血清HE4对子宫内膜癌诊断具有较好的特异性,但联合检测CA125与HE4可提高诊断的敏感性。

关 键 词:子宫内膜癌  肿瘤标志物  人附睾蛋白4

Clinical value of combined detection of CA125 and HE4 in diagnosis of endometrial carcinoma
Abstract:Objective:To investigate the clinical value of combined detection of CA125 and HE4 in diagnosis of endometrial carcinoma. Methods: The serum CA125 and HE4 levels 20 cases with normal endometrium 41 cases of endometrial atypical hyperplasia, 38 cases of endometrial cancer in patients were detected, and the results were statistically analyzed. Results :The serum HE4 and CA125 levels in patients with endometrial cancer were significantly higher than the atypical endometrial hyperplasia group and the control group, the difference was of statistically significant (P<0.05); and that in advanced endometrial cancer were significantly higher than patients in early stage, the difference was of statistically significant (P<0.05);The sensitivity in HE4 and CA125 of endometrial cancer were about the same (39.47% VS 34.21%), the difference was not of statistically significant (P>0.05), but the joint detection sensitivity was 57.89%, were increased than the single test, the difference was of statistically significant(P<0.05), but the serum HE4 was of a higher specificity than the combined detection (P<0.05), and the positive predictive value was significantly higher than CA125 (P<0.05). Conclusion: The serum HE4 in the diagnosis of endometrial carcinoma has good specificity, but the combined detectionof CA125 and HE4 can improve the diagnostic sensitivity.
Keywords:Endometrial cancer  Tumor markers  Human epididymis protein 4
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号