液基薄层细胞学筛查门诊人群宫颈癌的研究

目的探讨TCT技术和TBS方案对妇科门诊人群子宫颈癌筛查的准确性.方法随机收集妇产科门诊人群5 000例宫颈脱落细胞液基标本,采用TCT技术和TBS方案诊断.对细胞学阳性的即意义不明的不典型鳞状/腺细胞(ASCUS/AGUS)以上病变200例病例行阴道镜活检和组织病理学诊断.所有诊断均双盲进行.结果 TCT细胞学检出100%(9/9)的鳞状细胞癌(SCC),1例腺癌(AC),检出95%(38/40)的鳞状上皮内高度病变(HSIL),70.77%(92/130)的鳞状上皮内低度病变(LSIL).经统计学处理,液基细胞学对HSIL及SCC诊断与活检组织病理诊断的符合率显著高于对LSIL的诊断符合率(P＜0.01),两者差异有显著性.结论生育年龄段的妇女应定期进行液基细胞学筛查,TCT技术和TBS方案对宫颈上皮内病变,尤其是HSIL及其以上病变的筛查敏感性高.

Study on liquidbased thin-layer cytology for cervical cancer screening in clinic

Objective To investigate the accuracy of liquidbased thin layer cytology for cervical cancer screening in clinic.Method This study screened 5 000 women come from the linic The cytologic diagnosis was perpormed using the Bethesda system(TBS) on the ThinPrep Cytology Test (TCT) slides.Two hundred cases with abnormal cervical cytologic results received colposcopic examinations and multiple biopsies. The results of cytologic screening compared with the results of histopathologic diagnosis. All the diagnosises were performed in an independent and blinded fashion. Results All the cytological finds compared with the histopathological results,the TCT slides were able to detect 100%(9/9)of squmous cell carcinoma(SCC),95%(38/40)high grade squamous intraepithelial lesions(HSIL) and 70.77%(92/130)low grade squamous intraepithelial lesions(LSIL).Conclusion The liquidbased ThinPrep Cytology Test showed a high sensitivity for the detection of high grade squamous intraepithelial lesions and squamous cell carcinoma. Women ranged 20 50years old should receive liquidbased cytologic screening regularly.