Lipopolysaccharide-induced neutrophilic inflammation in the lungs differs with age |
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Authors: | Ito Yoko Betsuyaku Tomoko Nasuhara Yasuyuki Nishimura Masaharu |
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Affiliation: | First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan. |
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Abstract: | In aged humans and animals, lung injuries are generally more serious and prolonged. From a kinetic perspective, the authors thus assessed whether lung expression of proinflammatory cytokines were altered with age following intratracheal lipopolysaccharide (LPS) challenge in mice. Tumor necrosis factor-alpha, interleukin-1beta, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-2, and keratinocyte-derived chemokine were significantly higher in 65-week-old mice along with sustained neutrophilia when compared to 11-week-old mice at 72 hours, but not at earlier time points. The authors concluded that the degree of LPS-induced neutrophilic inflammation and the expression of these cytokines differ with age at later phases of acute lung injury. |
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