| 舱室内颅脑爆炸伤早期血浆S100B蛋白及脑水肿的变化及意义 |
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| 引用本文： | 黄晓龙,许民辉,赖西南.舱室内颅脑爆炸伤早期血浆S100B蛋白及脑水肿的变化及意义[J].创伤外科杂志,2008,10(3):268-270. |
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| 作者姓名： | 黄晓龙 许民辉 赖西南 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所神经外科、国家创伤、烧伤与复合伤重点实验室,重庆,400042 |
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| 摘 要： | 目的 观察舱室内大鼠颅脑爆炸伤早期血浆S-100B蛋白含量的变化及其意义.方法 采用自制舱室内大鼠颅脑爆炸伤模型,于伤后1、3、6、12、24、72小时取血,运用双抗体夹心法(ELISA法)检测S-100B蛋白含量,取脑组织测含水量并观察伤后病理变化.结果 伤后S-100B蛋白随时问延长而逐渐增高,24小时达高峰,72小时仍高于正常;脑含水量随时间延长而逐渐增加,6小时达高峰,之后逐渐下降,24小时内仍高于正常,72小时接近正常.结论 舱室内颅脑爆炸伤模型稳定可靠,早期检测血S-100B蛋白有助判断舱室内颅脑爆炸伤.
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| 关 键 词： | 颅脑损伤 S-100B蛋白 脑水肿 舱室 冲击波 舱室 颅脑爆炸伤 早期检测 血浆 白及 脑水肿 病理变化 意义 rats blast wave brain injury model period early during plasma 判断 稳定 时间 脑含水量 |
| 文章编号： | 1009-4237(2008)03-0268-03 |
| 修稿时间： | 2007年12月13 |
Expression of the S-100B in plasma during early period following a model of brain injury of blast wave in cabin in rats |
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| HUANG Xiao-long,XU Min-hui,LAI Xi-nan.Expression of the S-100B in plasma during early period following a model of brain injury of blast wave in cabin in rats[J].Journal of Traumatic Surgery,2008,10(3):268-270. |
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| Authors: | HUANG Xiao-long XU Min-hui LAI Xi-nan |
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| Institution: | HUANG Xiao-long,XU Min-hui,LAI Xi-nan(State Key Laboratory of Trauma,Burns , Combined Injury,Institute of Surgery Research,Department of Neurosurgery,Daping Hosptial,Third Military Medical University,Chongqing 400042,China)) |
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| Abstract: | Objective To investigate the expression of S-100B in brain injury of blast wave in cabin in rats.Methods Based on the model of brain injury of blast wave in cabin,the blood samples were obtained at 1h,3h,6h,12h,24h,72h after injury.The samples were studied by ELISA.Brain tissues were analyzed by wet-dry weight measurements and the microscope.Results The brain edema and S-100B kept increasing with the prolongation of injury time,reached the maximum level at 6h and 24h respectively after injury.Conclusion The... |
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| Keywords: | brain injury S-100B brain edema cabin blast wave |
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