高脂血症血脂和血糖及凝血因子变化的实验研究

目的　探讨高脂血症模型与患者血脂、血糖和凝血因子的变化及其关系。方法　用家兔制作高脂血症模型 3 0例并在临床随机抽取高脂血症患者和正常人各 40例 ,检测其血脂、血糖和凝血指标 ,将结果进行比较。结果　高脂血症家兔模型和临床病例的TC、TG、LDL -C和Glu显著升高 (均P <0 0 1) ,APTT和Fbg具有显著变化 (均P <0 0 1) ,PT和TT无改变 (均P >0 0 5 ) ;而HDL -C在模型中增高 (P <0 0 1)、临床病例没有变化 (P >0 0 5 )。结论　高脂血症模型与患者的血脂变化有所区别 ,但两者均可伴有糖代谢异常 ,同时可影响内源性凝血系统使血液呈高凝状态

Experiment Research of Alteration of Blood Lipids,Glucose and Blood Goagulation Factors in Hyperlipoidemia

Objective To study the changes and correlations of the blood lipids, glucose and blood coagulation factors in the animal models and patients with lipodystrophia. Methods The models of hyperlipoidemia were set up in 30 rabbits, and 40 cases of the hyperlipoidemia and 40 cases of the healthy subjects randomly were enrolled in this study. Their blood lipids, glucose and coagulation factors were detected. Results The serum levels of TC,TG,LDL-C and Glu in the rabbit models and patients with hyperlipoidemia notably increased compared with controls(P<0 01). Their APTT and Fbg levels also showed remarkable change (P<0 01), which PT and TT levels had not chang(P>0 05). HDL-C level increased in the rabbit models(P<0 01), but did not change in the patients(P>0 05). Conclusions The change of the blood lipids level in the rabbit models was different from that of the patients with hyperlipoidemia. But both may company the abnormality of carbohydrate metabolism, and hyperlipoidemia may affect the endogenous blood coagulation system to cause the blood to present the high coagulation.