Near-haploid cell line in megakaryoblastic transformation of Philadelphia-positive chronic myeloid leukemia |
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| Authors: | K M Mayne E J Maher |
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| Affiliation: | John Radcliffe Hospital, Oxford, England. |
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| Abstract: | A case of near haploidy in a patient with an acute megakaryoblastic transformation of Philadelphia (Ph)-positive chronic myeloid leukemia (CML) was studied. Cytogenetic studies revealed persistence of a Ph-positive pseudodiploid cell line and the emergence of a Ph-positive near-haploid cell line, i.e., 46,XX,t(9;22)(q34;q11)/28,XX,t(9;22),+8,+14,+18,+29. The near-haploid cell line is a rare cytogenetic finding. The patient rapidly deteriorated and died. |
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