类风湿性关节炎患者血清NO、NOS、TNF-α水平的变化及意义

目的：探讨了类风湿性关节炎患者血清NO、NOS和TNF-α含量的变化及意义。方法：分别应用放免法和化学法对36例类风湿性关节炎患者进行了血清NO、NOS和TNF-α含量测定，并以35名正常健康人作比较。结果：类风湿性关节炎患者在急性发作期血清NO、NOS、TNF-α水平非常显著地高于正常人组（P〈0．01）。经抗炎等治疗后1周其水平有所下降，但与正常人组比较，仍有显著性差异（P〈0．05）。结论：检测类风湿性关节炎患者血清NO、NOS和TNF-α含量的变化对了解病情、观察疗效和预后判断均具有十分重要的临床价值。

Clinical Significance of Changes of Serum NO, NOS and TNF-α Levels in Patients with Rheumatoid Arthritis

Objective To study the clinical significance of changes of serum NO, NOS and TNF - α levels in patients with rheumatoid arthritis. Methods The serum concentration of TNF - α was determined with radioimmunoassay （RIA） and NO, NOS contents were determined with chemical methods in 36 cases of rheumatoid arthitis as well as 35 controls. Results Serum concentration of NO, NOS and TNF - α during acute attack in patients with rheumatoid arthritis were significandy higher than those in controls （ P 〈 0.01 ）. After treatment for one week, serum NO, NOS and TNF - α levels were markedly decreased but still remained significandy higher than those in controls （P 〈 0.05）. Conclusion Detection of serum NO, NOS and TNF - α levels were useful for assessment of therapeutic efficacy and were of important clinicals value.