| 替米沙坦对冠状动脉介入术后糖尿病炎症因子的影响 |
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| 引用本文： | 金光临,刘幼文,员凤英,刘强,曾蘩芳,左辉华,师姗姗. 替米沙坦对冠状动脉介入术后糖尿病炎症因子的影响[J]. 岭南心血管病杂志, 2008, 14(5) |
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| 作者姓名： | 金光临 刘幼文 员凤英 刘强 曾蘩芳 左辉华 师姗姗 |
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| 作者单位： | 孙逸仙心血管医院内科,广东深圳,518020 |
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| 摘 要： | 目的观察替米沙坦对冠状动脉介入术后急性冠状动脉综合征合并糖尿病患者血炎症因子的影响。方法急性冠状动脉综合征合并糖尿病100例，在成功接受冠状动脉介入术后，随机分为替米沙坦组和常规药物组，随访6个月，用酶联免疫吸附法测定血高敏c反应蛋白、单核细胞趋化蛋白-1水平。术后6个月重复冠状动脉造影，比较两组间的晚期管腔丢失、支架再狭窄率及术后心血管不良事件发生率。结果治疗6个月时，两组的高敏c反应蛋白和单核细胞趋化蛋白～1均降低，而替米沙坦组下降更明硅（P〈0．05）。冠状动脉造影复查86例．两组支架再狭窄率差异无统计学意义，但替米沙坦组晚期管腔丢失及术后心血管不良事件发生率小于对照组。结论替米沙坦可降低冠状动脉介入术后急性冠状动脉综合征合并糖尿病患者血浆高敏C反应蛋白和单核细胞趋化蛋白-1，并可减少其介入术后晚期管腔的丢失及心血管不良事件发生率。
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| 关 键 词： | 替米沙坦 冠心病 糖尿病 高敏C反应蛋白 单核细胞趋化蛋白 冠状动脉介入术 内皮功能 |
Influence of telmisartan on plasma inflammatory cytokines in patients with diabetes mellitus after percutaneous coronary intervention |
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| JIN Guang-lin,LIU You-wen,YUAN Feng-ying,LIU Qiang,ZENG Fan-fang,ZUO Hui-hua,SHI Shan-shan. Influence of telmisartan on plasma inflammatory cytokines in patients with diabetes mellitus after percutaneous coronary intervention[J]. South China Journal of Cardiovascular Diseases, 2008, 14(5) |
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| Authors: | JIN Guang-lin LIU You-wen YUAN Feng-ying LIU Qiang ZENG Fan-fang ZUO Hui-hua SHI Shan-shan |
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| Affiliation: | JIN Guang-lin,LIU You-wen,YUAN Feng-ying,LIU Qiang,ZENG Fan-fang,ZUO Hui-hua,SHI Shan-shan(Department of Cardiology,Sun Yat-sen Cardiovascular Hospital,Shenzhen Guangdong 518020,China) |
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| Abstract: | Objectives To evaluate the influence of telmisartan on plasma inflammatory cytokines in patients with acute coronary syndrome(ACS) complicated with diabetes mellitus after percutaneous coronary intervention(PCI).Methods One hundred patients with ACS complicated with diabetes mellitus who had received PCI were randomly divided into telmisartan group and the control group.The patients in telmisartan group were given telmisartan besides standard drug treatment.After following-up for 6 months, The plasma high-s... |
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| Keywords: | Telmisartan Coronary artery disease Diabetes mellitus High-sensitivity C reactive protein Monocyte chemoattractant proteins Percutaneous coronary intervention Endothelial functions |
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