| 蝙蝠葛酚性碱对胰腺癌细胞株BXPC－3移植瘤K—ras mRNA表达的影响 |
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| 引用本文： | 边亚娟,李环,苏云明.蝙蝠葛酚性碱对胰腺癌细胞株BXPC－3移植瘤K—ras mRNA表达的影响[J].中医药信息,2010,27(2):89-92. |
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| 作者姓名： | 边亚娟 李环 苏云明 |
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| 作者单位： | 1. 黑龙江生物科技职业学院,黑龙江,哈尔滨,150025
2. 黑龙江中医药大学,黑龙江,哈尔滨,150040 |
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| 基金项目： | 2007黑龙江省自然科学基金课题 |
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| 摘 要： | 目的：探讨蝙蝠葛酚性碱（PAMD）抗胰腺癌作用靶点。方法：右腋皮下接种胰腺癌（BXPC－3）肿瘤细胞，经腹腔注射PAMD，连续用药21天，采用荧光定量PCR（Real—time PCR）技术检测肿瘤k-ras mRNA表达的情况。结果：PAMD高、中、低剂量均能下调BXPC－3荷瘤小鼠瘤组织中K—ras mRNA表达量，与模型对照组比较，差异具有统计学意义（P〈0.01）。结论：说明PAMD对BXPC－3荷瘤小鼠具有明显的抑瘤作用。
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| 关 键 词： | 胰腺癌 蝙蝠葛酚性碱 K—ras 抗肿瘤作用 |
Effects of PAMD on the Expression of K-ras mRNA of Mice-transplanted Pancreatic Cancer BXPC-3 Cells |
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| BIAN Ya-juan,LI Huan,SU Yun-ming.Effects of PAMD on the Expression of K-ras mRNA of Mice-transplanted Pancreatic Cancer BXPC-3 Cells[J].Information on Traditional Chinese Medicine,2010,27(2):89-92. |
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| Authors: | BIAN Ya-juan LI Huan SU Yun-ming |
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| Institution: | BIAN Ya-juan1,LI Huan2,SU Yun-ming2 (1.Biotechnology Occupation College in Heilongjiang,Harbin 150025,China,2.Heilongjiang University of Chinese Medicine,Harbin 150040,China) |
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| Abstract: | Objective:To research PAMD action target against pancreatic cancer.Method:Nude mice were inoculated with pancreatic cancer BXPC-3 cells under right armpit and injected with PAMD by abdominal cavity about 21days,and k-ras mRNA expression was detected by Real-time fluorescent quantitative PCR.Results:The high,moderate,and low dose groups of PAMD can all reduce k-ras mRNA expression of nude mice inoculated with pancreatic cancer BXPC-3 cells more obviously than model control group(P<0.01).Conclusion:which show... |
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| Keywords: | K-ras |
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