| 咖啡因作为中枢腺苷受体拮抗剂的应用 |
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| 引用本文： | 王潭,席娜娜,郑荣远. 咖啡因作为中枢腺苷受体拮抗剂的应用[J]. 国外医学(药学分册), 2009, 0(4): 249-253 |
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| 作者姓名： | 王潭 席娜娜 郑荣远 |
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| 作者单位： | 温州医学院附属第一医院神经内科; |
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| 基金项目： | 浙江省部共建基金资助项目(No.WZJ2005-2-041) |
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| 摘 要： | 咖啡因是中枢神经系统兴奋药，在机体的多个系统中发挥广泛的药理学作用。腺苷是重要的神经调质，通过不同亚型的腺苷受体调节多种病理生理过程。近年来，咖啡因作为中枢腺苷受体拮抗剂在基础研究与临床应用方面越来越受到重视。大量实验证明，通过不同剂量、不同时相给予咖啡因可以改变腺苷受体不同亚型的表达，增强或减弱其生物学效应，对某些中枢神经系统疾病（如帕金森病、阿尔茨海默病、脑缺血缺氧等）起到预防或治疗作用。
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| 关 键 词： | 咖啡因 腺苷受体 帕金森病 阿尔茨海默病 缺氧缺血 脑 |
Application of caffeine as an adenosine receptor antagonist in central nervous system |
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| WANG Tan,XI Na-na,ZHENG Rong-yuan. Application of caffeine as an adenosine receptor antagonist in central nervous system[J]. Foreign Medical Sciences(Section of Pharmarcy), 2009, 0(4): 249-253 |
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| Authors: | WANG Tan XI Na-na ZHENG Rong-yuan |
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| Affiliation: | WANG Tan,XI Na-na,ZHENG Rong-yuan(Department of Neurology,The First Affiliated Hospital,Wenzhou Medical College,Wenzhou 325000,China) |
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| Abstract: | Caffeine is a stimulant in central nervous system,and also has a wide range of pharmacological effect on many other organs.Adenosine,as an important neuromodulator,regulates pathological and physiological processes through different adenosine receptors.The non-selective antagonism of caffeine against adenosine receptors has attracted more and more attention.Recent studies demonstrated that caffeine can either up-regulate or down-regulate different subtype expressions of adenosine receptors in case of differ... |
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| Keywords: | caffeine adenosine receptor Parkinson＇s disease Alzheimer＇s disease hypoxia-ischemia,brain |
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