| 超敏C反应蛋白、白细胞介素-6与家兔急性心房颤动的关系及黄油干预 |
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| 引用本文： | 徐志伟,胡建新.超敏C反应蛋白、白细胞介素-6与家兔急性心房颤动的关系及黄油干预[J].国外医学：心血管疾病分册,2009(5):308-311. |
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| 作者姓名： | 徐志伟 胡建新 |
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| 作者单位： | 南昌大学研究生院医学部;南昌大学第二附属医院心血管内科; |
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| 摘 要： | 目的：探讨黄油干预家兔血清超敏C反应蛋白（hs—CRP）、白细胞介素-6（IL-6）水平及对急性心房颤动（房颤）的影响。方法：30只家兔随机分为正常组（72=15）、黄油组（＂=15），黄油组预先给予人造黄油灌胃4周。通过开胸植入食道调搏电极（程序刺激与Burst刺激相结合）刺激肺静脉建立家兔急性房颤模型。根据实验结果是否诱发出房颤将家兔分为房颤组与非房颤组。应用ELISA双抗体夹心方法测定血清中hs—cRP、IL-6的水平。比较房颤组与非房颤组刺激前血清中hs—CRP、IL-6的水平。比较黄油组与正常组刺激前与刺激后血清中hs—cRP、IL-6的水平，并进行统计学分析。结果：房颤组刺激前血清hs—CRP、IL-6水平均高于非房颤组（P〈0．01）。黄油组血清hs—CRP、IL-6的水平均高于正常组（P〈0．05）。黄油组的房颤诱发率均明显高于正常组（P〈0．05）。结论：刺激前血清hs—CRP、IL-6水平越高，房颤越易诱发，房颤持续时间越长。预先控制血清hs—CRP、IL-6水平升高就可能会有效抑制房颤的发生、发展。表明炎症状态可能参与了房颤的发生、发展。
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| 关 键 词： | 心房颤动 超敏C反应蛋白 白细胞介素-6 黄油 家兔 |
Relationship between serum high-sensitivity C-reactive protein,Interleukin-6 and acute atrial fibrillation in rabbits and the effects of butter. |
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| Authors: | XU Zhi-wei HU Jian-xin |
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| Institution: | XU Zhi-wei1,HU Jian-xin2(1.Grade 2006,Department of Medical Science,Postgraduate School,2.Department of Cardiovascular Medicine,the Second Affiliated Hospital,Nanchang University,Nanchang 330006) |
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| Abstract: | Objective:This study was sought to explore the effects of the butter on the serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6) and acute atrial fibrillation of rabbits.Methods:30 rabbits were randomly divided into normal control group(n=15) and butter group(n=15).The butter group was given artificial butter orally for 4 weeks,then received trans-esophagus pacing electrodes through thoracotomy(combination of process pacing and burst) to stimulate pulmonary vein for establishing rabbit mode... |
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| Keywords: | Atrial fibrillation C-reactive protein Interleukin-6 Butter Rabbit |
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