Development of GABAergic neurons in rat visual cortex as identified by glutamate decarboxylase-like immunoreactivity |
| |
| Authors: | J.R. Wolff H. Böttcher T. Zetzsche W.H. Oertel B.M. Chronwall |
| |
| Affiliation: | 1. Department of Anatomy, Univ. of Göttingen, Göttingen, F.R.G.;2. Department of Neurology, Univ. of München, München F.R.G. |
| |
| Abstract: | The development of glutamate decarboxylase (GAD)-like immunoreactivity was studied in albino rats. GAD-positive structures appeared and accumulated in a characteristic temporo-spatial sequence: from embryonic day 18 onwards in lamina (L) I and subplate; after birth in L I-II, L IV-V and deep L VI including white matter; after two weeks in superficial L I, L II to L III-IV border, L V and L VI-white matter. GAD-positive axon varicosities formed perisomatic 'baskets' on L V pyramids on postnatal day 8 and a few days later on those L II-III. During the third week GAD-positive structures attained adult densities and established different laminar patterns in the primary and secondary visual areas. |
| |
| Keywords: | ontogenesis glutamate decarboxylase GABAergic neurons visual cortex immunocytochemistry |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
