| 手性药物对映体在药效学与药代动力学的相互作用 |
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| 引用本文： | 顿彬,刘会臣. 手性药物对映体在药效学与药代动力学的相互作用[J]. 中国临床药理学杂志, 2005, 21(1): 66-69 |
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| 作者姓名： | 顿彬 刘会臣 |
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| 作者单位： | 白求恩国际和平医院临床药理室,河北,石家庄,050082 |
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| 摘 要： | 当手性药物以外消旋体供药用时，其对映体间就可能发生药效学和药代动力学的相互作用。本文综述了手性药物对映体间的药效学和药代动力学相互作用及其对手性药物药效学和药代动力学立体选择性的影响。
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| 关 键 词： | 手性药物 药效学 药代动力学 相互作用 立体选择性 |
| 文章编号： | 1001-6821(2005)01-0066-04 |
Interactions between the enantiomers of chiral drugs on the pharmacodynamics and pharmacokinetics |
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| DUN Bin,LIU Hui-chen. Interactions between the enantiomers of chiral drugs on the pharmacodynamics and pharmacokinetics[J]. The Chinese Journal of Clinical Pharmacology, 2005, 21(1): 66-69 |
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| Authors: | DUN Bin LIU Hui-chen |
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| Abstract: | Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate. The pharmacodynamic and pharmacokinetic interactions between the enantiomers of chiral drugs, and their effects on the stereoselectivity in pharmacodynamics and pharmacokinetics of chiral drugs were reviewed in this paper. |
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| Keywords: | chiral drug pharmacodynamics pharmacokinetics drugs interaction stereoselectivity |
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