Accumulation of methylsulfonyl derivatives of some bronchial-seeking polychlorinated biphenyls in the respiratory tract of mice. |
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| Authors: | A Bergman I Brandt B Jansson |
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| Affiliation: | 1. Section of Organic Chemistry, Environmental Toxicology Unit, Wallenberg Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden;2. Department of Toxicology, Biomedical Centre, University of Uppsala, S-751 23 Uppsala, Sweden;3. Special Analytical Laboratory, National Swedish Environment Protection Board, Wallenberg Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden |
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| Abstract: | Seventeen polychlorobiphenyls (PCBs), 14C-labeled and/or unlabeled, were studied with regard to their deposition as such or as metabolites in the lung tissues after iv or ip injection in mice. Four of these compounds were known by autoradiography to possess affinity for bronchial tissues. Lung extracts of mice treated with the 11 labeled PCBs were analyzed in a partition scheme to indicate the presence of hydroxylated and/or methylsulfonyl metabolites. Extracts of lungs from mice treated with the unlabeled compounds were analyzed by gas chromatography. The extracts that appeared to contain methylsulfonyl metabolites were further analyzed by mass fragmentography. Five of the biphenyls studied were each found to appear in the lungs as two isomeric methylsulfonyl PCBs. The structures of the major metabolites were confirmed by comparison with synthetic reference compounds. One of the biphenyls previously known to accumulate in the bronchi was found not to occur in the lung as methylsulfonyl derivatives, but most probably only as the unchanged compound. None of the remaining 11 PCBs studied was found to occur as methylsulfonyl derivatives in the lung. |
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| Keywords: | Present address: Department of Pharmacology Biomedical Centre Faculty of Veterinary Medicine The Swedish University of Agricultural Sciences Box 573 S-751 23 Uppsala. To whom correspondence should be sent. |
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