| 妊娠期高血压疾病孕妇血内皮素、一氧化氮、肿瘤坏死因子水平变化及意义 |
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| 引用本文： | 夏红卫,刘先知,赵宁,阳宪初,袁海虹,苏花莉,莫云. 妊娠期高血压疾病孕妇血内皮素、一氧化氮、肿瘤坏死因子水平变化及意义[J]. 实用妇产科杂志, 2009, 25(3) |
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| 作者姓名： | 夏红卫 刘先知 赵宁 阳宪初 袁海虹 苏花莉 莫云 |
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| 作者单位： | 1. 广西壮族自治区妇幼保健院,广西,南宁,530003
2. 广州儿童医院,广东,广州,510120 |
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| 基金项目： | 广东省医学科研基金立项课题 |
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| 摘 要： | 目的:探讨一氧化氮(NO)、内皮素-1(ET-1)和肿瘤坏死因子(TNF)含量在妊娠期高血压疾病中的变化,及其与发病之间的关系.方法:将我院产科分娩的96例妊娠期高血压疾病患者(妊娠期高血压疾病组),根据病情轻重分为妊娠期高血压组(39例),重度子痫前期组(53例).采用酶联免疫吸附试验检测所有患者静脉和新生儿脐血血浆中ET-1,用放射免疫法检测血清中NO、TNF含量并与48例正常孕妇(正常妊娠组)作比较.结果:妊娠期高血压疾病组与正常妊娠组相比,母血与脐血中ET-1水平升高(P＜0.01;P＜0.05),NO水平降低(P＜0.01;P＜0.05),TNF水平升高(P＜0.05),重度子痫前期组较妊娠期高血压组ET-1、TNF水平均升高(P＜0.05),NO水平降低(P＜0.05).结论:妊娠期高血压疾病患者ET-1合成增加,NO释放减少,TNF分泌过多,三者调控失衡在妊娠期高血压疾病的发病中具有重要作用.
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| 关 键 词： | 妊娠期高血压疾病 内皮素 一氧化氮 肿瘤坏死因子 |
The Clinical Significance of Endothelin,Nitric Oxide and Tumor Necrosis Factor in Pregnant Women with Hypertensive Disorder Complicating Pregnancy |
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| XIA Hongwei,LIU Xianzhi,ZHAO Ning,et al.. The Clinical Significance of Endothelin,Nitric Oxide and Tumor Necrosis Factor in Pregnant Women with Hypertensive Disorder Complicating Pregnancy[J]. Journal of Practical Obstetrics and Gynecology, 2009, 25(3) |
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| Authors: | XIA Hongwei LIU Xianzhi ZHAO Ning et al. |
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| Affiliation: | 1.Maternal and Child Health Care Hospital of Guangxi;Nanning Guangxi 530003;China;2.The Children Hospital of Guangzhou;Guangzhou Guangdong 510120;China |
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| Abstract: | Objective:To approach the variation of serum endothelin(ET-1),nitrogen oxide(NO) and tumor necrosis factor(TNF) in the course of hypertensive disorder complicating pregnancy.Methods:96 of pregnant women with gestational hypertension in our hospital were divided into mild group(39 cases) and severe group(53 cases),according to its degree.The content of ET-1,NO and TNF were detected by ELISA from blood sample of these 96 women and cord blood of their newborn.The data were compared with 48 normal pregnant wome... |
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| Keywords: | Hypertensive disorder complicating pregnancy Endothelin Nitrogen oxide Tumor necrosis factor |
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