心钠素,抗利尿激素在正常和缺氧新生儿水钠代谢中的作用

为了阐明心钠素（ＡＮＰ）和抗利激素（ＡＤＨ）在正常和缺氧新生儿生后早期体液平衡中的作用，测定了４４例正常新生儿和３６例缺氧新生儿生后第１、３、７天血浆心钠素（ＰＡＮＰ）、抗利尿激素（ＰＡＤＨ）以及血、尿各项指标。结果表明：正常新生儿第１天ＰＡＮＰ和ＰＡＤＨ都升高，两者之间存在着负相关关系；尿量、尿钠、尿渗透压和ＡＮＰ呈正相关；缺氧新生儿的ＰＡＮＰ和ＰＡＤＨ均较正常儿升高，其第３天的悄量、尿钠和尿渗

Effect of atrial natriuretic peptide and antidiuretic hormone on metalism of fluid and natriumin in normal and hypoxic newborns

In order to study the fluid homeostasis in hypoxic newborns, plasma natriuretic peptide (PANP), an-tiuretic hormone (PADH) and other parameters related to fluid and salt metabolism on the lst, 3rd and 7th day of lifewere measured in 36 cases of hypoxic newborns, compared with 44 cases of normal newborns. The results indicated thaton the lst day of life of normal nweborns, the values of PANP and PADH are increased. The 1evels of PANP, but notof PADH, were positively related to those of urinary volume, sodium, and osmolality. In hypoxic newborns, bothPANP and PADH levels on the lst day of life were higher than those of normal newborns, the values of urinary volume,sodium and osmolality on the 3rd day of life were also higher than those of normal newborns. These data suggest thatANP and ADH may play an important role in balance of fluid and electrolyte in early newborns. The potent diuretic andnatriuretic responses of ANP compensate the fluid retention resulted from increased levels of ADH, and then it helps im-prove the recovery of pulmonary function and absorption of pulmonary edema in hypoxic newborns.