| 5-氟尿嘧啶控释植入剂的体外释药试验 |
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| 引用本文： | 贺银成,何国英,乔建国,周亚魁,史海安. 5-氟尿嘧啶控释植入剂的体外释药试验[J]. 医学新知杂志, 2000, 10(4): 203-204 |
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| 作者姓名： | 贺银成 何国英 乔建国 周亚魁 史海安 |
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| 作者单位： | 湖北医科大学附属第二医院普外科,武汉,430071 |
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| 摘 要： | 以５－氟尿嘧啶（５－Ｆｕ）为药芯，硅橡胶管为骨架，制成５－Ｆｕ控释植入剂。该控释剂为直径２ｍｍ、长２５ｍｍ的管型胶囊，壁厚０．５ｍｍ。每只胶囊含５－Ｆｕ１３．２ｍｇ。用三重蒸馏水作释放介质，行体外释药试验，高效液相色谱（ＨＰＬＣ）测定５－Ｆｕ释放量。结果表明控释制剂可保持药物零级释放，恒定释药量为４０μｇ／ｄ左右，时间长达２４周以上。
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| 关 键 词： | 氟尿嘧啶 控释系统 体外 试验 |
Evaluation of 5-Fluorouracil Controlled Release Implant Made of Silastic Elastomer |
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| He Yincheng,He Guoyin,Qiao Jianguo,et al The Second Affiliated Hospital,Hubei Medical University,Wuhan. Evaluation of 5-Fluorouracil Controlled Release Implant Made of Silastic Elastomer[J]. Journal of New Medicine, 2000, 10(4): 203-204 |
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| Authors: | He Yincheng He Guoyin Qiao Jianguo et al The Second Affiliated Hospital Hubei Medical University Wuhan |
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| Affiliation: | He Yincheng,He Guoyin,Qiao Jianguo,et al The Second Affiliated Hospital,Hubei Medical University,Wuhan 430071 |
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| Abstract: | |
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| Keywords: | Fluorouracil Drug delivery system In vitro |
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