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Carnosine-Induced Changes in the Development of Spermatogenic Epithelial Cells in Senescence Accelerated SAM Mice
Authors:A?V?Gopko  Email author" target="_blank">A?Yu?KulibinEmail author  M?L?Semenova  S?T?Zakhidov
Institution:(1) Embryology Department, Biological Faculty, M. V. Lomonosov Moscow State University, Russia
Abstract:Carnosine significantly increased the number of spermatogonia and Sertoli cells in mice prone (SAMP1) and resistant (SAMR1) to accelerated aging and appreciably reduced cell yield in meiosis and spermiogenesis in SAMP1 mice. In experimental SAMP1 mice catastrophic changes in the number of gametes were paralleled by intensive degradation of the spermatogenic epithelium. In SAMR1 mice treated with carnosine highly ordered spermatogenic structure was preserved. __________ Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 8, pp. 206–209, August, 2005
Keywords:carnosine  SAMP1 mice  SAMR1 mice  spermatogenic cells
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