原发性高血压家系中高血压患者及其亲属血脂、血糖的比较

目的:探讨原发性高血压家系中高血压患者及其一级亲属的体重、血脂、血糖及胰岛素水平变化的临床意义。方法:收集10个原发性高血压家系成员共84例的资料(血压、体重、腰围、臀围、体重指数(BMI)等资料)并检测血脂、血糖和胰岛素水平。分3组:高血压患者组(A组)、正常血压一级亲属组(B组)、正常血压非一级亲属组(孙辈)(C组)。结果:(1)A组的年龄明显大于B、C组,血压增高与年龄显著相关,3组分别为(57.25±15.96)(48.38±7.95)(35.78±17.84),均P<0.05];(2)3组的身高、体重、BMI、腰围、臀围、腰围/臀围(WHR)、腹围均无显著差异;3组的体重指数(BMI)>23,属超重,总BMI=23.84±4.13,原发性高血压家系BMI的均值高于正常水平。(3)A组的甘油三酯(TG)>1.7 mmol/L、极低密度脂蛋白胆固醇(VIDL-C)>0.8 mmol/L均高于正常水平,3组间有显著性差异,P<0.05。3组的高密度脂蛋白胆固醇(HDL-C)均小于0.9 mmol/L,3组间无显著性差异(P>0.05),原发性高血压家系的HDL-C的均值低于正常水平。(4)3组的空腹血糖(FPG)、糖化血红蛋白A1(HbA1c)、空腹血胰岛素(FINS)、空腹C肽(cp)、稳态模型胰岛素抵抗指数(HOMAIR)均无显著差异。结论:原发性高血压家系的高血压患者的TG、VIDL-C异常,可能与原发性高血压的发生有关。

Study on Lipids and Glucose in Primary Hypertension Patients and Their Relative of Normal Blood Pressure in Chinese Primary Hypertension Pedigrees

Objective To investigate the clinical significance of changes in lipids and glucose in primary hypertension patients and their relative of normal blood pressure in primary hypertension pedigrees.Methods the clinical data,blood pressure,body weight,waist circumference,hip circumference,waist-hip ratio,height,body mass index(BMI)and lipids,fasting plasma glucose,fasting insulin were determined in 10 primary hypertension pedigrees.Results (1) The age was older in A group(57.25±15.96) as compared with those in B group(48.38±7.95) and C group(35.78±17.84),(P<0.05).(2)The BMI was higher in primary hypertension pedigrees,(BMI=23.84±4.13).No significant difference in body weight,waist circumference,hip circumference,waist-hip ratio,height,body mass index(BMI) was found among 3 groups.(P>0.05).BMI was higher were determined in primary hypertension pedigrees.(3) TG level was higher 1.7 mmol/L、VIDL-C level was higher 0.8 mmol/L,significant difference in was found among 3 groups.(P<0.05).HDL-C level was lower 0.9 mmol/L,no significant difference in was found among 3 groups.(P>0.05).HDL-C level was lower were determined in primary hypertension pedigrees.(4)FPG、HbA1、FINS、cp、HOMAIR level no significant difference was found among 3 groups.(P>0.05).Conclusion(1)The increase in TG、VIDL-C seems to be related to the development of primary hypertension pedigrees.