参麦注射液合并化疗治疗晚期恶性肿瘤的临床研究

 目的　探讨参麦注射液对恶性肿瘤化疗增效减毒作用。方法　采用参麦注射液配合化疗与单用化疗对照治疗恶性肿瘤病人108例，并对疗效、免疫功能及毒副作用进行评价。结果　参麦注射液治疗组有效率(56.45%)高于对照组(39.13%)，以胃癌明显；参麦注射液治疗组口腔溃疡及静脉炎的发生率明显低于对照组(P＜0.05或0.01)，而且对照组白细胞明显下降，治疗组不明显；参麦注射液治疗组治疗后NK细胞数、CD4及CD4/CD8值升高，CD8下降(P＜0.05或0.01)，而对照组变化不明显(P＞0.05)，两组体液免疫指标治疗前后变化不明显。结论　参麦注射液对恶性肿瘤化疗有增效、减毒作用，且能提高细胞免疫功能，值得临床推广应用。

The Clinic Study for Treatment of Canmai Liquor Combining with Chemotherapy for the Late-stage Malignant Tumors

Objective To observed the effects of canmai liquor in combination with chemotherapy on the increase of chemotherapeutic results,reduction of chemotherapy induced toxicities and on human functions.Methods 108 cases with late stage cancer were treated with canmai liquor combining with chemotherapy or only chemotherapy.The results of treatment,immune functions and chemotherapy induced toxicities were observe.Results The remission rate of the trial group was 56.45% and significantly higher than that(39.13%) of the control group( P <0 05).The Chemotherapy induced morbidity of oral mucosal ulcer and venulitis of the trial group reduced in comparison to the control group( P <0 05 or 0.01).White blood cell count reduced significantly in control group( P <0 01),but not in trial group.Changes of cellular immune function:In the trial group,the natural Killer Cells,CD 4 and CD 4/CD 8 ration increased,CD 8 reduced( P <0 05 or 0.01).The humoral immunity of two hroups had no obvious change( P >0 05).Conclusion Canmai liquor in combination with chemotherapy could raise the remission rate of treatment,reduce the chemotherapy induced toxicities and improve the cellular immune function.