Acute myocardial infarct size reduction by timolol administration |
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| Affiliation: | 1. Section of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, Washington, DC, USA;2. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;1. Los Angeles County Hospital and USC Medical Center, Los Angeles, CA, United States;2. Lehigh Valley Hospital and Health Network, Allentown, PA, United States;3. University of South Florida, Tampa, FL, United States;1. Department of Cardiac Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China;2. Department of Cardiac Vascular Surgery, Linfen City Center Hospital, Linfen 041000, Shanxi, China;1. Royal Stoke Hospital, University Hospitals of North Midlands, Newcastle Road, Stoke on Trent ST46QG, United Kingdom;2. Sultan Qaboos University Hospital, Muscat, Oman |
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| Abstract: | A multicenter, randomized, double-blind study was performed to evaluate the effects of timolol administered early during the evolution of acute myocardial infarction. Of 144 patients entered into the trial, 73 were assigned to timolol and 71 to placebo. The 2 groups were well matched at baseline. The timolol group had reduced myocardial ischemia and infarct size as measured by an accelerated reduction of ST-vector magnitude, a significant reduction of creatine kinase (CK) release and significantly smaller changes in QRS vector variables. The predicted maximal QRS vector change and cumulative CK release for any given initial ST-vector magnitude was significantly reduced in the timolol-treated patients. Furthermore, QRS evolution time and CK release time were significantly reduced after intravenous timolol, as were the need for analgesics and the pain scores. Timolol treatment was well tolerated overall. |
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