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The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines |
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| Authors: | Bea Pauwels Annelies EC Korst Greet GO Pattyn Hilde AJ Lambrechts Juliette AE Kamphuis Christel MJ De Pooter Godefridus J Peters Filip Lardon and Jan B Vermorken |
| Institution: | (1) Laboratory of Cancer Research and Clinical Oncology, Department of Medical Oncology, University of Antwerp (UA/UZA), Wilrijk, Belgium;(2) Department Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands;(3) Department of Radiotherapy, St Augustinus Hospital, Wilrijk, Belgium |
| Abstract: | BackgroundGemcitabine (dFdC) is an active antitumour agent with radiosensitising properties, shown both in preclinical and clinical studies. In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. |
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