我院2011年135例药品不良反应报告分析

目的分析药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法对医院2011年收集的135例药品不良反应报告,分别从患者年龄、给药途径、用药情况、药品不良反应累及器官或系统及临床表现等方面进行统计、分析。结果不良反应以老年患者发生率最高;由抗微生物类药物引发的例数最多,抗微生物类药中又以头孢类、喹诺酮类、青霉素类发生率最高;给药途径主要以静脉滴注为主;临床表现以皮肤及附件损害和胃肠道反应多见。结论临床应重视药品不良反应监测工作,减少或避免药品不良反应发生。

Analysis on 135 Cases of Adverse Drug Reaction Reporters in Our Hospital during 2011

Objective To analyze the characteristics and regularity of adverse drug reactions（ADR） in our hospital in order to provide reference for clinical rational drug use. Methods A hundred and thirty-five cases of ADR reports collected in our hospital during 2011 were statistically analyzed in respect of age, routes of administration, medication condition, involved organs and systems and clinical manifestations. Results The incidence rate in the elderly patients was highest. Most of ADR cases were caused by antibacterials. The incidence rate induced by cephalosporins, quinolones and penicillins was highest. Intravenous drip was the main route of administration leading to ADR. The most common clinical manifestations were the damage of skin and adnexa as well as gastrointestinal reac-tions. Conclusion Clinical should paid attention to the monitoring work of ADR for reducing or avoiding the occurrence of ADR.