| 舒马曲坦胶囊的制备与质量控制 |
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| 引用本文： | 张敬如,赵凯,黄复生,王昆. 舒马曲坦胶囊的制备与质量控制[J]. 中国药业, 2012, 21(21): 32-34 |
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| 作者姓名： | 张敬如 赵凯 黄复生 王昆 |
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| 作者单位： | 中国人民解放军第三军医大学基础部病原生物学教研室,重庆400038 |
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| 基金项目： | 重庆市基金面上项目,项目编号：CSTC2010BB5168 |
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| 摘 要： | 目的制备舒马曲坦胶囊并建立其质量控制方法。方法采用高效液相色谱(HPLC)法测定制剂中舒马曲坦。结果舒马曲坦质量浓度在50～1 600 ng/mL范围内与峰面积线性关系良好(r=0.999 9),平均回收率为(105.73±4.58)%,RSD为4.33%(n=6),日内、日间精密度平均RSD为2.20%和2.59%。结论质量控制方法稳定可靠,可用于舒马曲坦胶囊的质量控制。
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| 关 键 词： | 舒马曲坦胶囊 质量控制 高效液相色谱法 |
Preparation and Quality Control of Sumatriptan Capsule |
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| Zhang Jingru,Zhao Kai,Huang Fusheng,Wang Kun. Preparation and Quality Control of Sumatriptan Capsule[J]. China Pharmaceuticals, 2012, 21(21): 32-34 |
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| Authors: | Zhang Jingru Zhao Kai Huang Fusheng Wang Kun |
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| Affiliation: | (Department of Pathogenic Biology, Third Military Medical University, Chongqing, China 400038) |
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| Abstract: | Objective To prepare sumatriptan capsules and establish the quality standard for them. Methods HPLC was used to deter-mine the content of sumatriptan. Results Sumatriptan showed a good linear relationship in the range of 50-1 600 ng/mL（r =0. 999 9） and the average recovery was up to （105.73±4.58）%, RSD was 4. 33%.The mean intra-day RSD and inter-day RSD were 2.20% and 2.59%. Conclusion This standard is precise and can be used for the quality control of sumatriptan capsules. |
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| Keywords: | Sumatriptan Capsules quality control HPLC |
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