口服马钱子碱后小鼠体内的药动学研究

 目的　研究马钱子碱在小鼠体内的药动学。方法　小鼠灌胃2种剂量60及40mg·kg^-1后用荧光分光光度法测定不同时间的血药浓度和组织浓度。应用3P87药动学软件程序对数据进行计算机处理。结果　 2种剂量的主要动力学参数:Ka分别为3.56和4.3h^-1;Ke分别为0.54和0.59h^-1;t_1/2Ka分别为0. 19和0.16h;t_1/2Ke分别为1.28和1.17h;V_C分别为14.59和13.37L·kg^-1;CL_s分别为7.87和7.89L·h^-1·kg^-1;AUC分别为7.62和5.07h·mg·L^-1。组织中以肝脏浓度最高,然后依次是肾、心、肺和脑,血中浓度最低。结论　2种剂量马钱子碱在小鼠体内的C-T变化均符合一室开放模型,马钱子碱在小鼠体内分布,消除迅速。

Study on Pharmacokinetics of brucine in mice

OBJECTIVE To study the pharmacokinetics of brucineinmice METHODS After intra gastric administ ra ctionofbru cineat doseso f6 0and 4 0mg·kg^-1 inmice ,the plasm aandtis sueconce ntrat ionsatd iffernet timepointswer edete rminedb yfluoresce ncespect rophotometry Thedat awere proc esse dwith 3P 87pharmacokineti cprogram RESULTS Theph armacok ineticpa rametersofthet wodoseswereas follows:Kawere 3.56 and 4.31h^-1;Kewere 0.54 and 0.59h^-1;t_1/2Ka were 0.19and 0.16h,t_1/2Ke were 1.28 and 1.17h ;Vc were 14.59and 13.37L·kg^-1;CL_s were 7.87and 7.89L·h^-1·kg^-1;AUC were 7.62and 5.07h·mg·L^-1,respectively The brucine concen tration intheli verwast hehighe standth osein thekidney ,heart,lung ,braina ndpl asmadecr sedsequen tially CONCLUSION Atdosesof 60,40mg·kg^-1 inmice,the conc entration timecurve sofbru cinewer efoundt obefi ttedtoone compar tme ntopenmo delwi thfir storder abs orption Thedistr ibuti ona nd eliminatio nwererapid.