汞蒸气对雄性小鼠的生殖毒性研究 |
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引用本文: | 陈小玉,徐力平.汞蒸气对雄性小鼠的生殖毒性研究[J].中国公共卫生学报,1993,12(6):372-374. |
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作者姓名: | 陈小玉 徐力平 |
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作者单位: | 河南医科大学劳动卫生教研室,河南医科大学劳动卫生教研室,河南医科大学劳动卫生教研室,河南医科大学医学实验中心 郑州 450052,郑州 450052,郑州 450052 |
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摘 要: | 实验小鼠每天暴露于汞蒸气中染毒2h,每周6天,连续2个月。结果发现,汞在睾丸组织呈现一定的蓄积作用。睾丸组织形态学观察发现,染毒组出现曲细精管层次紊乱、层次减少以及退行性变等病理变化。血清睾酮含量降低,与对照组相比有显著性差异(P〈0.05)。睾丸及附睾乳酸脱氢酶同功酶X相对含量,各剂量组对照组比无显著性差异(P〉0.05)。染毒组精子精量减少、活动能力下降、畸形率增高,0.146和0.338mg
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关 键 词: | 汞蒸气 睾丸 生殖毒性 汞中毒 |
Study of Reproductive Toxicity of Mercury Vapor on Male Mice |
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Authors: | Chen Xiaoyu |
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Institution: | Zhengzhou 450052 |
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Abstract: | The reproductive toxicity of mercury vapor on male BALB/c mice was studied. Animals were exposed by inhala- tion to mercury vapor at the doses of 0. 036, 0. 146,and 0. 338mg/ms for 2h/day, 6 days/w over 2 months, respective- ly. It was found that mercury was accumulated in the testis. There were decreased layers of the spermatogenic cell and dis- organized spermatogenic cells. The seminiferous rubles degen- erated at the dose of 0. 338mg/m~3, The serum testosterone level in the experimental groups obviously decreased (p<0. 05). In the activity of LDH-X of the testis and epididymis there were no differences between the experimental groups and the control group (p>0. 05). Sperm analysis showed that sperm count and sperm motility significantly decreased and the rate of sperm abnormality increased(compared with the control group p<0. 05 or p<0. 01). The results showed dose-re- sponse relationships. |
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Keywords: | Mercury vapor Testis Reproductive toxicity |
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