Chemical composition and anticancer,antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei |
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| Affiliation: | 1. Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China;2. Department of Entomology and MOA Key Laboratory for Monitoring and Environment-Friendly Control of Crop Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China;3. State Key Laboratory of Green Pesticide and Agricultural Bioengineering, Guizhou University, Guiyang, China;1. Laboratório de Farmacologia Experimental, Universidade Federal do Oeste do Pará – UFOPA, Brazil;2. Laboratório de Farmacologia, Instituto Esperança de Ensino Superior – IESPES, Brazil;3. Laboratório de Neurofarmacologia Experimental, Universidade Federal do Pará – UFPA, Brazil;4. Laboratório de Bioquímica Medicinal, Universidade Federal de São João del-Rei – UFSJ, Brazil;5. Faculdade de Farmácia, Universidade Federal do Rio de Janeiro – UFRJ, Brazil;6. Laboratório de Biotecnologia Vegetal, Universidade Federal do Oeste do Pará – UFOPA, Brazil |
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| Abstract: | The essential oil from Cedrelopsis grevei leaves, an aromatic and medicinal plant from Madagascar, is widely used in folk medicine. Essential oil was characterized by GC–MS and quantified by GC–FID. Sixty-four components were identified. The major constituents were: (E)-β-farnesene (27.61%), δ-cadinene (14.48%), α-copaene (7.65%) and β-elemene (6.96%). The essential oil contained a complex mixture consisting mainly sesquiterpene hydrocarbons (83.42%) and generally sesquiterpenes (98.91%). The essential oil was tested cytotoxic (on human breast cancer cells MCF-7), antimalarial (Plasmodium falciparum), antiinflammatory and antioxidant (ABTS and DPPH assays) activities. C. grevei essential oil was active against MCF-7 cell lines (IC50 = 21.5 mg/L), against P. falciparum, (IC50 = 17.5 mg/L) and antiinflammatory (IC50 = 21.33 mg/L). The essential oil exhibited poor antioxidant activity against DPPH (IC50 > 1000 mg/L) and ABTS (IC50 = 110 mg/L) assays. A bibliographical review was carried out of all essential oils identified and tested with respect to antiplasmodial, anticancer and antiinflammatory activities. The aim was to establish correlations between the identified compounds and their biological activities (antiplasmodial, anticancer and antiinflammatory). According to the obtained correlations, 1,4-cadinadiene (R2 = 0.61) presented a higher relationship with antimalarial activity. However, only (Z)-β-farnesene (R2 = 0.73) showed a significant correlation for anticancer activity. |
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