Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring |
| |
| Affiliation: | 1. Department of Pharmacology (the State-Province Key Laboratories of Biomedicine–Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150086, China;2. Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin 150086, China;1. Center for Environmental Research and Children''s Health (CERCH), School of Public Health, University of California, Berkeley, 1995 University Avenue, Berkeley, CA 94704, USA;2. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA 30341, USA;1. Division of Cardiology, TongRen Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China;2. Division of Spine, Department of Orthopedics, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai, China;3. Department of Thoracic Surgery, First People’s Hospital of Yunnan Province, Kunming, 650031, China;1. Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang 050017, China;2. Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University, 050017, China;3. Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;4. Experimental Center for Teaching, Hebei Medical University, Shijiazhuang 050017, China;5. Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China |
| |
| Abstract: | Thyroid disrupting chemicals can potentially disrupt brain development. Two studies investigating the effect of the antibacterial compound triclosan on thyroxine (T4) levels in rats are reported. In the first, Wistar rat dams were gavaged with 75, 150 or 300 mg triclosan/kg bw/day throughout gestation and lactation. Total T4 serum levels were measured in dams and offspring, and all doses of triclosan significantly lowered T4 in dams, but no significant effects on T4 levels were seen in the offspring at the end of the lactation period. Since this lack of effect could be due to minimal exposure through maternal milk, a second study using direct per oral pup exposure from postnatal day 3–16 to 50 or 150 mg triclosan/kg bw/day was performed. This exposure pointed to significant T4 reductions in 16 day old offspring in both dose groups. These results corroborate previous studies showing that in rats lactational transfer of triclosan seems limited. Since an optimal study design for testing potential developmental neurotoxicants in rats, should include exposure during both the pre- and postnatal periods of brain development, we suggest that in the case of triclosan, direct dosing of pups may be the best way to obtain that goal. |
| |
| Keywords: | Triclosan Rat Developmental Thyroid disrupting chemical (TDC) |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
