Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L) |
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| Institution: | 1. Analytical & Testing Center, Sichuan University, Chengdu 610065, China;2. College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China;1. Department of Chemical Science, Biochemistry Unit, Afe Babalola University, Ado-Ekiti, Nigeria;2. Department of Medicine, Ekiti State University, Ado-Ekiti, Nigeria;3. Department of Clinical Science, Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria;1. Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad Iran;2. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Reproductive Biology and Toxicology Laboratory, UNESCO Satellite Center of Trace Element Research & School of Studies in Zoology, Jiwaji University, Gwalior, Madhya Pradesh, India;2. Department of Zoology, DDU Gorakhpur University, Gorakhpur, Uttar Pradesh, India;3. School of Pharmacy and Technology Management (SPTM), Shri Vile Parle Kelavani Mandal’s (SVKM''s),Narsee Monjee Institute of Management Studies (NMIMS), Mukesh Patel Technology Park, Babulde, Bank of Tapi River, Mumbai-Agra Road, Shirpur, Dist. Dhule-India |
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| Abstract: | The present study investigated the acute, subchronic and genotoxicity of turmeric essential oil (TEO) from Curcuma longa L. Acute administration of TEO was done as single dose up to 5 g of TEO per kg body weight and subchronic toxicity study for thirteen weeks was done by daily oral administration of TEO at doses 0.1, 0.25 and 0.5 g/kg b.wt. in Wistar rats. There were no mortality, adverse clinical signs or changes in body weight; water and food consumption during acute as well as subchronic toxicity studies. Indicators of hepatic function such as aspartate aminotransferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) were unchanged in treated animals compared to untreated animals. Oral administration of TEO for 13 weeks did not alter total cholesterol, triglycerides, markers of renal function, serum electrolyte parameters and histopathology of tissues. TEO did not produce any mutagenicity to Salmonella typhimurium TA-98, TA-100, TA-102 and TA-1535 with or without metabolic activation. Administration of TEO to rats (1 g/kg b.wt.) for 14 days did not produce any chromosome aberration or micronuclei in rat bone marrow cells and did not produce any DNA damage as seen by comet assay confirming the non toxicity of TEO. |
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