Neurotoxic effect of linamarin in rats associated with cassava (Manihot esculenta Crantz) consumption |
| |
| Affiliation: | 1. Laboratorio de Farmacotoxicología, Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Circuito Gonzalo Aguirre Beltrán s/n, Zona Universitaria, Xalapa, Veracruz, Mexico;2. Laboratorio de Biología y Química Molecular de Frutas, Instituto de Ciencias Básicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico;3. Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico;1. Key Laboratory of Advanced Display and System Applications of Ministry of Education, Shanghai University, P.O.B. 143, 149 Yanchang Rd., Shanghai 200072, PR China;2. Center for Organic Photonics and Electronics Research (OPERA), Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395, Japan;1. Department of Cardiac Surgery, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom;2. Translational Health Sciences, University of Bristol, Bristol, United Kingdom;3. Department of Cardiology, Bristol Heart Institute and Bristol Royal Hospital for Children, Bristol, United Kingdom;4. Centre for Cell, Gene & Tissue Therapeutics, Royal Free London NHS Foundation Trust, London, United Kingdom;1. Spoiled Hike LLC, Stanardsville, VA 22973, USA;2. Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium;3. Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;4. Gibb Epidemiology Consulting LLC, 3033 Wilson Boulevard, Suite 700, Arlington, VA 22201, USA;5. George Washington University Milken Institute School of Public Health, Washington, DC 20052, USA;6. Exponent Inc., 1150 Connecticut Ave NW #1100, Washington, DC 20036, USA;1. School of Nursing Sciences, University of Nairobi, Kenya;2. Department of Comparative Medicine, Oregon Health & Science University (OHSU), USA;3. Department of Pharmacology and Pharmacognosy, University of Nairobi, Kenya;4. Mannheimer Foundation, Inc., Homestead, FL, USA;5. Department of Medical Physiology, University of Nairobi, Kenya;6. Oregon Institute of Occupational Health Sciences, OHSU, USA;7. Department of Neurology, OHSU, USA |
| |
| Abstract: | Cassava (Manihot esculenta Crantz) is a plant widely used for food consumption in different processed products in rural areas of Africa, Asia, and Latin America. Cassava is a good source of carbohydrates and micronutrients. However, if it is not adequately processed or the consumer has nutritional deficiencies, then its cyanogenic glycoside (i.e., linamarin and lotaustralin) content makes it potentially neurotoxic. In the present study, the neurotoxic effects of different concentrations of linamarin (0.075, 0.15, 0.22, and 0.30 mg/kg) contained in cassava juice were evaluated in the open field and swim tests to identify locomotor alterations in adult male Wistar rats. The linamarin concentration in cassava juice was determined by high-performance liquid chromatography, and the juice was administered intraesophageally for 28 days. The results suggested that the consumption of linamarin in cassava juice increased the number of crossings and rearings in the open field test and caused behavioral deficiency, reflected by lateral swimming, in the swim test on days 21 and 28 of treatment. These alterations are possibly related to neuronal damage caused by linamarin in cassava juice in structures of the central nervous system involved in motor processing. |
| |
| Keywords: | Cassava Neurotoxic Linamarin Locomotor activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
